Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise (2024)

Turner, J. E., Aldred, S., Witard, O. C., Drayson, M. T., Moss, P. M. (2010). Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. Brain, behavior, and immunity, 24(8), 1362-1370. https://doi.org/10.1016/j.bbi.2010.07.239

Turner, James E. ; Aldred, Sarah ; Witard, Oliver C. et al. / Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. In: Brain, behavior, and immunity. 2010 ; Vol. 24, No. 8. pp. 1362-1370.

@article{a2c9b12e314f4bc4a759733ffbd750b9,

title = "Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise",

abstract = "Exercise induces mobilisation of CD8+ T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector potential. This study investigated whether effector-memory cells also account for the CD8TL egress from peripheral blood following exercise. As latent Cytomegalovirus (CMV) infection is associated with a robust expansion in the number and proportion of effector-memory CD8TLs, we also investigated if CMV serostatus was a determinant of the CD8TL responses to exercise.Fourteen males (Mean age 35, SD±14 yrs), half of whom were CMV seropositive (CMV+), ran on a treadmill for 60min at 80% {\.V}O2 max. Blood was collected at baseline, during the final minute of exercise, and 15min and 60min thereafter. CD8TL memory subsets were characterised by flow cytometry, using the cell-surface markers CD45RA, CD27, and CD28.The results confirmed that CD8TLs with an effector-memory phenotype (CD27-CD28-CD45RA+/-) exhibited the largest increase during exercise (+200% to +250%), and also showed the largest egress from blood 60min post-exercise (down to 40% of baseline values). Strikingly, the mobilisation and subsequent egress of total CD8TLs was nearly twice as large in CMV+ individuals. This effect appeared specific to CD8TLs, and was not seen for CD4+ T lymphocytes or total lymphocytes. This effect of CMV serostatus was largely driven by the higher numbers of exercise-responsive effector-memory CD8TLs in the CMV+ participants.This is the first study to demonstrate that infection history is a determinant of immune system responses to exercise.",

keywords = "CD8 T lymphocytes, Cytomegalovirus, Exercise, Human, Immune surveillance, Lymphocytopenia, Lymphocytosis, Memory lymphocytes, Migration, Stress",

author = "Turner, {James E.} and Sarah Aldred and Witard, {Oliver C.} and Drayson, {Mark T.} and Moss, {Paul M.} and Bosch, {Jos A.}",

year = "2010",

month = nov,

doi = "https://doi.org/10.1016/j.bbi.2010.07.239",

language = "English",

volume = "24",

pages = "1362--1370",

journal = "Brain, behavior, and immunity",

issn = "0889-1591",

publisher = "Academic Press Inc.",

number = "8",

}

Turner, JE, Aldred, S, Witard, OC, Drayson, MT, Moss, PM 2010, 'Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise', Brain, behavior, and immunity, vol. 24, no. 8, pp. 1362-1370. https://doi.org/10.1016/j.bbi.2010.07.239

Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. / Turner, James E.; Aldred, Sarah; Witard, Oliver C. et al.
In: Brain, behavior, and immunity, Vol. 24, No. 8, 11.2010, p. 1362-1370.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise

AU - Turner, James E.

AU - Aldred, Sarah

AU - Witard, Oliver C.

AU - Drayson, Mark T.

AU - Moss, Paul M.

AU - Bosch, Jos A.

PY - 2010/11

Y1 - 2010/11

N2 - Exercise induces mobilisation of CD8+ T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector potential. This study investigated whether effector-memory cells also account for the CD8TL egress from peripheral blood following exercise. As latent Cytomegalovirus (CMV) infection is associated with a robust expansion in the number and proportion of effector-memory CD8TLs, we also investigated if CMV serostatus was a determinant of the CD8TL responses to exercise.Fourteen males (Mean age 35, SD±14 yrs), half of whom were CMV seropositive (CMV+), ran on a treadmill for 60min at 80% V̇O2 max. Blood was collected at baseline, during the final minute of exercise, and 15min and 60min thereafter. CD8TL memory subsets were characterised by flow cytometry, using the cell-surface markers CD45RA, CD27, and CD28.The results confirmed that CD8TLs with an effector-memory phenotype (CD27-CD28-CD45RA+/-) exhibited the largest increase during exercise (+200% to +250%), and also showed the largest egress from blood 60min post-exercise (down to 40% of baseline values). Strikingly, the mobilisation and subsequent egress of total CD8TLs was nearly twice as large in CMV+ individuals. This effect appeared specific to CD8TLs, and was not seen for CD4+ T lymphocytes or total lymphocytes. This effect of CMV serostatus was largely driven by the higher numbers of exercise-responsive effector-memory CD8TLs in the CMV+ participants.This is the first study to demonstrate that infection history is a determinant of immune system responses to exercise.

AB - Exercise induces mobilisation of CD8+ T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector potential. This study investigated whether effector-memory cells also account for the CD8TL egress from peripheral blood following exercise. As latent Cytomegalovirus (CMV) infection is associated with a robust expansion in the number and proportion of effector-memory CD8TLs, we also investigated if CMV serostatus was a determinant of the CD8TL responses to exercise.Fourteen males (Mean age 35, SD±14 yrs), half of whom were CMV seropositive (CMV+), ran on a treadmill for 60min at 80% V̇O2 max. Blood was collected at baseline, during the final minute of exercise, and 15min and 60min thereafter. CD8TL memory subsets were characterised by flow cytometry, using the cell-surface markers CD45RA, CD27, and CD28.The results confirmed that CD8TLs with an effector-memory phenotype (CD27-CD28-CD45RA+/-) exhibited the largest increase during exercise (+200% to +250%), and also showed the largest egress from blood 60min post-exercise (down to 40% of baseline values). Strikingly, the mobilisation and subsequent egress of total CD8TLs was nearly twice as large in CMV+ individuals. This effect appeared specific to CD8TLs, and was not seen for CD4+ T lymphocytes or total lymphocytes. This effect of CMV serostatus was largely driven by the higher numbers of exercise-responsive effector-memory CD8TLs in the CMV+ participants.This is the first study to demonstrate that infection history is a determinant of immune system responses to exercise.

KW - CD8 T lymphocytes

KW - Cytomegalovirus

KW - Exercise

KW - Human

KW - Immune surveillance

KW - Lymphocytopenia

KW - Lymphocytosis

KW - Memory lymphocytes

KW - Migration

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=77957240274&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.bbi.2010.07.239

DO - https://doi.org/10.1016/j.bbi.2010.07.239

M3 - Article

C2 - 20638470

SN - 0889-1591

VL - 24

SP - 1362

EP - 1370

JO - Brain, behavior, and immunity

JF - Brain, behavior, and immunity

IS - 8

ER -

Turner JE, Aldred S, Witard OC, Drayson MT, Moss PM, Bosch JA. Latent Cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise. Brain, behavior, and immunity. 2010 Nov;24(8):1362-1370. doi: https://doi.org/10.1016/j.bbi.2010.07.239